Oxiracetam was introduced to the medical community in 1984. Since then this nootropic drug has gone through hundreds of clinical trials with the focus of memory enhancement and cognitive path formations leading the motivation for this research. The research began with mice yet safety concerns were quickly set aside as no noticeable side effects were observed.
The same year the drug was created studies shifted to human participants after safety was confirmed. Early on Oxiracetam showed great promise for treating Alzheimer’s, dementia and neurological deterioration. These findings became more noticeable especially when administered during testing periods and after studying information.
The Original Nootropic
Some of the early testing of Oxiracetam showed researchers its ability to improve avoidance acquisition during training sessions. This study performed with rats showed insights into how memory retention was increased in comparison to placebo groups given the same avoidance tests.
After conclusions were beginning to form as to how this drug could be useful as a nootropic substance, trials began with elderly individuals to solidify the claims that were being made early on. Since all cells naturally deteriorate over time it made sense to start with an elderly group that had undergone this natural degeneration. This study showed an increase in patient vigilance as well as an improved long term memory span in comparison to the placebo group. This vigilance points to the lack of mental fatigue a user would experience when supplementing with Oxiracetam.
Once a solid base of information had formed around the efficacy of this drug studies were amped up to include specific individuals that were known for having poor memory retention as well as low cognitive performance. 40 subjects all with moderate dementia were given Oxiracetam at an increasing rate over a quarterly year period. During the double blind study the researchers found that the patients who were administered Oxiracetam began to show an increase in auditory recognition through performance tests. They also showed an increase in memory and even word fluency as conversations became more articulated than before. Furthermore these results improved as dosing increased.
How it works:
Fast forward a decade and Oxiracetam along with its parent Racetams are still being closely reviewed for other possible benefits. Research had almost conclusively proven how taking Oxiracetam will increase a number of cognitively related performance tasks including memory, cognition speed and even vocabulary.
Now that there is more information about how neurons fire in the brain and what influences these connections, researchers have begun to look at how this drug is effecting our brain functions. Through more advanced studies researchers are delving deeper into how this brain enhancing drug effects these connections. They found that Oxiracetam has an ability to break the blood brain barrier to directly influence how our GABAB receptors react as a neurons fire. Traditionally the GABA receptors control the amount of anxiety a person feels when neuron activity is increased. Oxiracetam decreases this role allowing the person to increase neuron firing without the associated anxiety that usually follows. This process makes way for an increase memory and attention to detail as a result. Racetams as a group have the ability to increase acetylcholine without effecting the base line state. Acetylcholine acts a neurotransmitter in the brain as a part of the parasympathetic nervous system, leading to more efficient energy processing within the brain.
What we know now
- Oxiracetam Improves long and short term memory
- Reduces stress levels through GABA receptor manipulation
- Performance improves when being tested especially under stress
- Greatly effects auditory memory
- Can reverse the effects of degenerative diseases such as dementia and Alzheimer’s
- Stacks well with vitamins and nutrients
Stacking with Oxiracetam:
Vitamin C supports many functions of a healthy body especially one in the recovery stage. Working with Oxiracetam it can improve the effects of memory enhancement. It is important to note that vitamin C comes in two forms. Ascorbic acid and citric acid. Ascorbic acid is the only form of vitamin C that has shown to enhance the qualities of Oxiracetam. In fact research is starting to show that citric acid has little to no effect on the immune system in comparison to ascorbic acid. It’s important to read product labels carefully to make sure you are getting the proper version of vitamin C, as citric acid is better kept as a preservative rather than a health food supplement.
Choline is one of the more popular supplements used to stack with Oxiracetam. It’s similar to B vitamins in the way that the body is able to synthesis it within the liver. It is found in commonly in beans and other high protein foods specifically the liver. Oxiracetam works symbiotically with Choline so it is important that your body has enough when using this nootropic drug. Studies have shown that Oxiracetam alone will prevent the reduction of acetylcholine when undergoing highly stressful situations that can lead to amnesia.